How do Endocannabinoids affect the body?

Endocannabinoids receptors are a type of protein found on the surface of cells in the body that are responsible for mediating the effects of endocannabinoids, which are naturally produced by the body. Endocannabinoids are a group of compounds that interact with these receptors to regulate various physiological processes such as pain, appetite, mood, and immune function.

The two main types of endocannabinoids receptors are CB1 and CB2. CB1 receptors are primarily found in the brain and nervous system, specifically in the hippocampus, cerebellum, and basal ganglia. They also found in other organs such as the liver, kidney, and lungs. These receptors play a role in regulating various functions including memory, mood, pain perception, and appetite, as well as the psychoactive effects of tetrahydrocannabinol (THC), the main psychoactive compound found in cannabis.

CB2 receptors, on the other hand, are primarily found in the immune system, including the spleen and other immune cells. They play a role in regulating inflammation and immune response, and they are also found in other organs such as the liver and kidneys.

Endocannabinoids and their receptors are also involved in the body's response to injury and disease. For example, endocannabinoids are known to play a role in the body's response to inflammation and pain, and they also have been shown to have potential therapeutic benefits in conditions such as multiple sclerosis, cancer, and Alzheimer's disease.

It's worth mentioning that there are also other receptors have been discovered that have similar effects like GPR55 and GPR18 and research is ongoing to understand their role in the endocannabinoid system.

In summary, endocannabinoids receptors are a crucial component of the endocannabinoid system, which plays a critical role in regulating various physiological processes and response to injury and disease. They are potential therapeutic targets for a wide range of medical conditions.